From Rome:

• Freeeway till Orte;

• From Orte E\45 direction Cesena until Sansepolcro;

• from Sansepolcro follow the indications for Anghiari;

From Bologna:

• E45 direction Rome;
• until Sansepolcro Sud;
• from Sansepolcro follow the indications for Anghiari;

From Florence:

• Freeeway A1 till Arezzo;
• from Arezzo follow the indications for Anghiari;

By train:
By train until Arezzo, then there are a lot of bus for the town of Anghiari.